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    Neurobiol Aging. 2010 Jan;31(1):8-16. Epub 2008 Apr 28.

    RANTES upregulation in the Alzheimer's disease brain: a possible neuroprotective role.

    Tripathy D, Thirumangalakudi L, Grammas P.

    Source

    Garrison Institute on Aging, Department of Neuropsychiatry and Behavioral Sciences, Texas Tech University Health Sciences Center, 3601 4th Street Stop 9424, Lubbock, TX 79430, United States.

    Abstract

    Numerous studies demonstrate inflammatory proteins in the brain and microcirculation in Alzheimer's disease (AD) and implicate inflammation in disease pathogenesis. However, emerging literature suggests that neuroinflammation can also be neuroprotective. The chemokine RANTES has been implicated in neurodegenerative diseases including AD. The objectives of this study are to determine the expression of RANTES in AD microvessels, its regulation in endothelial cells and its effects on neuronal survival. Our data show elevated expression of RANTES in the cerebral microcirculation of AD patients. Treatment of neurons in vitro with RANTES results in an increase in cell survival and a neuroprotective effect against the toxicity of thrombin and sodium nitroprusside. Oxidative stress upregulates RANTES expression in rat brain endothelial cells. Developing strategies to augment neuroprotection and diminish inflammatory activation of multifunctional mediators such as RANTES holds promise for the development of novel neuroprotective therapeutics in AD.

    PMID:
    18440671
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2803489
    Free PMC Article

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