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Clin Biochem. 2008 Jul;41(10-11):914-6. doi: 10.1016/j.clinbiochem.2008.03.015. Epub 2008 Apr 11.

Post-methionine load test: A more sensitive tool to reveal hyperhomocysteinemia in Alzheimer patients?

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  • 1Department of Neuroscience and Biomedical Technology, University of Milano-Bicocca, via Cadore 48, 20052 Monza (MI), Italy. gloria.galimberti@unimib.it

Abstract

OBJECTIVE:

To identify the real number of hyperhomocysteinemic Alzheimer's patients who may benefit from homocysteine-lowering therapy.

METHODS:

Basal and post-methionine load homocysteine levels were assessed by rp-HPLC system.

RESULTS:

PML test revealed twice as many hyperhomocysteinemic AD subjects with respect to the fasting analysis.

CONCLUSION:

PML test resulted useful in detecting higher number of hyperhomocysteinemic AD patients who may have the chance of an early folate treatment.

PMID:
18439912
[PubMed - indexed for MEDLINE]
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