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Radiother Oncol. 2008 Jun;87(3):361-6. doi: 10.1016/j.radonc.2008.04.001. Epub 2008 Apr 23.

Phase I trial of neoadjuvant concurrent chemoradiotherapy with S-1 and weekly irinotecan in locally advanced rectal cancer.

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  • 1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.


S-1 is a novel, oral fluoropyrimidine and a known radiosensitizer. We conducted a phase I trial to establish a schedule of S-1/irinotecan with standard pelvic radiotherapy as a preoperative treatment of locally advanced rectal cancer. Our findings suggest that this new combination is feasible and well tolerable.

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