Neuron. 2008 Apr 24;58(2):165-7. doi: 10.1016/j.neuron.2008.04.007.

Schizophrenia: genome, interrupted.

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Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Abstract

Structural chromosomal variation is increasingly recognized as an important contributor to human diseases, particularly those of neurodevelopment, such as autism. A current paper makes a significant advance to schizophrenia genetics by establishing an association with rare copy number variants (CNV), which are over-represented in neurodevelopmental genes.

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Review Copy-number variants in neurodevelopmental disorders: promises and challenges. [Trends Genet. 2009]
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Schizophrenia: genome, interrupted.
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