How chemotherapy damages the central nervous system

J Biol. 2008;7(4):11. doi: 10.1186/jbiol73. Epub 2008 Apr 22.

Abstract

Chemotherapy adversely affects cognitive function both acutely and chronically, but little is known about the underlying mechanisms. A new study shows that short-term chemotherapy causes not only acute injury to progenitor cells, but also delayed damage to myelin.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / adverse effects*
  • Central Nervous System / drug effects*
  • Central Nervous System / pathology
  • Cognition / drug effects*
  • Drug-Related Side Effects and Adverse Reactions*
  • Humans
  • Myelin Sheath / metabolism*

Substances

  • Antineoplastic Agents