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Nat Struct Mol Biol. 2008 May;15(5):531-3. doi: 10.1038/nsmb.1411. Epub 2008 Apr 27.

The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi.

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  • 1Department of Genetics, Harvard Medical School, and Department of Molecular Biology, Massachusetts General Hospital, CPZN7250, 185 Cambridge Street, Boston, Massachusetts 02114, USA.

Abstract

The exonuclease ERI-1 negatively regulates RNA interference in Caenorhabditis elegans and Schizosaccharomyces pombe, and is required for production of some C. elegans endogenous small interfering RNAs. We show that ERI-1 performs 3' end processing of the 5.8S ribosomal RNA in both C. elegans and S. pombe. In C. elegans, two protein isoforms of ERI-1 are localized to the cytoplasm, and each has distinct functions in ribosomal RNA processing and negative regulation of RNA interference.

PMID:
18438419
[PubMed - indexed for MEDLINE]
PMCID:
PMC2910399
Free PMC Article
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