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Am J Kidney Dis. 2008 May;51(5):741-7. doi: 10.1053/j.ajkd.2007.12.030. Epub 2008 Mar 20.

Metabolic syndrome and self-reported history of kidney stones: the National Health and Nutrition Examination Survey (NHANES III) 1988-1994.

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  • 1Division of Nephrology, University of Arizona, Tucson, AZ 85724, USA. bradfordw9@hotmail.com

Abstract

BACKGROUND:

Metabolic syndrome affects approximately 25% of the American population. Components of metabolic syndrome, such as obesity, hypertension, and diabetes, were associated with kidney stone disease, but no published large-scale study examined the association between metabolic syndrome and history of kidney stones.

STUDY DESIGN:

Cross-sectional analysis. The American Heart Association and National Heart, Lung, and Blood Institute statement on metabolic syndrome was used to define metabolic syndrome.

SETTING & PARTICIPANTS:

A national probability sample of the US population National Health and Nutrition Examination Survey aged 20 years and older.

PREDICTOR:

Metabolic syndrome as defined by the American Heart Association and National Heart, Lung, and Blood Institute.

OUTCOMES & MEASUREMENTS:

Self-reported history of kidney stones.

RESULTS:

Of all adults older than 20 years, 4.7% reported a history of kidney stones. The prevalence of self-reported history of kidney stones increased with the number of metabolic syndrome traits from 3% with 0 traits to 7.5% with 3 traits to 9.8% with 5 traits. After adjustment for age and other covariates, the presence of 2 or more traits significantly increased the odds of self-reported kidney stone disease. The presence of 4 or more traits was associated with an approximate 2-fold increase in odds of self-reported kidney stone disease.

LIMITATIONS:

Cross-sectional design, absence of dietary data.

CONCLUSION:

Metabolic syndrome traits are associated with a self-reported history of kidney stones. This association should be verified in prospective studies.

PMID:
18436084
[PubMed - indexed for MEDLINE]
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