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J Phys Chem B. 2008 May 22;112(20):6288-91. doi: 10.1021/jp8012706. Epub 2008 Apr 24.

The strong MRI relaxivity of paramagnetic nanoparticles.

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  • 1Lab for Bio-Environmental Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Science, Beijing, China.


We developed a method to synthesize paramagnetic nanoparticles of Gd@C82(OH)22+/-2. Such nanoparticles are with ordered microstructures and have strong MRI proton relaxation in vitro/vivo. Compared with commercial Gd-DTPA, a 12x MRI relaxivity of Gd@C82(OH)22+/-2 nanoparticles with ordered microstructures was achieved in vitro. The small Gd@C82(OH)22+/-2 nanoparticles, approximately 65nm, could easily escape the RES uptake in vivo; this opens the door for their clinical applications.

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