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J Med Virol. 2008 Jun;80(6):937-41. doi: 10.1002/jmv.21138.

Unexpected dramatic increase in CD4+ cell count in a patient with AIDS after enfuvirtide treatment despite persistent viremia and resistance mutations.

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  • 1Clinic of Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy. soria.alessandro@hsr.it

Abstract

An unexpected dramatic immune recovery was observed in a patient with full-blown AIDS receiving enfuvirtide-based antiretroviral therapy after multiple treatment failures. A complex interplay of viral and host factors, including the control of X4 viruses and proviral burden, may favor immune restoration with HIV neutralizing activity, despite persistent viremia.

PMID:
18428138
[PubMed - indexed for MEDLINE]
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