Zh Nevrol Psikhiatr Im S S Korsakova. 2007;107(12):21-4.

[The study on the assessment of the new levodopa drug--stalevo (levodopa/carbidopa/entacapone), in treatment of Parkinson's disease in out-patient clinical practice (the results of the open START-M)].

[Article in Russian]

Boĭko AN, Batysheva TT, Minaeva NG, Babina LA, Vdovichenko TV, Zhuravleva EIu, Shikhkerimov RK, Malykhina EA, Khozova AA, Zaĭtsev KA, Kostenko EV.

Abstract

Despite significant symptomatic effect of levodopa, in most patients the stable 24 hour's effect changed for alterations of movement symptoms (fluctuations, dyskinesia) after 2-3 years of the therapy. These complications may be reduced due to the constant (physiologic) stimulation of post-synaptic dopamine receptors that, to a certain degree, provides the drug stalevo, which contains levodopa and 2 enzyme inhibitors, dopa decarboxylase (carbidopa) and catechol-O-methyltransferase (entacapone). The results of the study demonstrated beneficial effects of stalevo as compared to traditional therapy in patients with "wearing off" and "on-off" phenomena.

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Use of the new levodopa agent Stalevo (levodopa/carbidopa/entacapone) in the treatment of Parkinson's disease in out-patient clinical practice (the START-M open trial). [Neurosci Behav Physiol. 2008]
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[The study on the assessment of the new levodopa drug--stalevo (levodopa/carbido...
[The study on the assessment of the new levodopa drug--stalevo (levodopa/carbidopa/entacapone), in treatment of Parkinson's disease in out-patient clinical practice (the results of the open START-M)].
Zh Nevrol Psikhiatr Im S S Korsakova. 2007 ;107(12):21-4.

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[The study on the assessment of the new levodopa drug--stalevo (levodopa/carbidopa/entacapone), in treatment of Parkinson's disease in out-patient clinical practice (the results of the open START-M)].

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