Trends Biochem Sci. 2008 May;33(5):195-200. Epub 2008 Apr 20.

Sticking together? Falling apart? Exploring the dynamics of the interactome.

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School of Biotechnology and Biomolecular Sciences, University of New South Wales, NSW 2052, Australia. m.wilkins@unsw.edu.au <m.wilkins@unsw.edu.au>

Abstract

Advances in techniques for the study of protein-protein interactions have dramatically improved our understanding of the interactome. However, we know little about the dynamics of this complex system. To better understand the dynamics of the interactome, it is important to consider what happens when single proteins are perturbed. Changes in protein abundance and post-translational modification can function as switches in the interactome, affecting protein-complex assembly and function. Changes in protein sequence or a dramatic increase in abundance might cause a promiscuous gain of interactions. These effects are not identical for all proteins and will differ depending on the number and type of interaction partners that a protein has.

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Trends Biochem Sci. 2009 Jan;34(1):1-2; author reply 3.

PMID:: 18424047; [PubMed - indexed for MEDLINE]

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