Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Cell. 2008 Apr 18;133(2):217-22. doi: 10.1016/j.cell.2008.04.001.

miRiad roles for the miR-17-92 cluster in development and disease.

Author information

  • McKusick-Nathans Institute of Genetic Medicine, Departments of Pediatrics and Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. jmendell@jhmi.edu

Abstract

MicroRNAs (miRNAs) encoded by the miR-17-92 cluster and its paralogs are known to act as oncogenes. Expression of these miRNAs promotes cell proliferation, suppresses apoptosis of cancer cells, and induces tumor angiogenesis. New work reveals essential functions for these miRNAs not only in tumor formation but also during normal development of the heart, lungs, and immune system.

PMID:
18423194
[PubMed - indexed for MEDLINE]
PMCID:
PMC2732113
Free PMC Article

Images from this publication.See all images (1)Free text

Figure 1
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk