Engineering protease specificity made simple, but not simpler

Nat Chem Biol. 2008 May;4(5):270-1. doi: 10.1038/nchembio0508-270.

Abstract

Engineering protease specificity has been a long sought research goal. New findings on OmpT, an outer membrane protease from Escherichia coli, reveal the remarkable success of a simple strategy.

Publication types

  • Comment
  • News

MeSH terms

  • Catalytic Domain
  • Models, Molecular
  • Protein Engineering*
  • Serine Endopeptidases / chemistry
  • Serine Endopeptidases / metabolism*
  • Substrate Specificity

Substances

  • Serine Endopeptidases
  • omptin outer membrane protease