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Biochem Biophys Res Commun. 2008 Jun 13;370(4):657-62. doi: 10.1016/j.bbrc.2008.04.030. Epub 2008 Apr 15.

A mis-expression study of factors affecting Drosophila PNS cell identity.

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  • 1Department of Biosciences and Nutrition, Karolinska Institute, Novum 141 86, Huddinge, Sweden; Life sciences, Södertörns Högskola, 141 89, Huddinge, Sweden.


Drosophila PNS sense organs arise from single sensory organ precursor (SOP) cells through a series of asymmetric divisions. In a mis-expression screen for factors affecting PNS development, we identified string and dappled as being important for the proper formation of adult external sensory (ES) organs. string is a G2 regulator. dappled has no described function but is implicated in tumorigenesis. The mis-expression effect from string was analysed using timed over expression during adult ES-organ and, for comparison, embryonic Chordotonal (Ch) organ formation. Surprisingly, string mis-expression prior to SOP division gave the greatest effect in both systems. In adult ES-organs, this lead to cell fate transformations producing structural cells, whilst in the embryo organs were lost, hence differences within the lineages exist. Mis-expression of dappled, lead to loss and duplications of entire organs in both systems, potentially affecting SOP specification, in addition to affecting neuronal guidance.

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