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Genome Biol. 2008 Apr 17;9(4):R73. doi: 10.1186/gb-2008-9-4-r73.

Erect wing regulates synaptic growth in Drosophila by integration of multiple signaling pathways.

Author information

  • 1School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.

Abstract

BACKGROUND:

Formation of synaptic connections is a dynamic and highly regulated process. Little is known about the gene networks that regulate synaptic growth and how they balance stimulatory and restrictive signals.

RESULTS:

Here we show that the neuronally expressed transcription factor gene erect wing (ewg) is a major target of the RNA binding protein ELAV and that EWG restricts synaptic growth at neuromuscular junctions. Using a functional genomics approach we demonstrate that EWG acts primarily through increasing mRNA levels of genes involved in transcriptional and post-transcriptional regulation of gene expression, while genes at the end of the regulatory expression hierarchy (effector genes) represent only a minor portion, indicating an extensive regulatory network. Among EWG-regulated genes are components of Wingless and Notch signaling pathways. In a clonal analysis we demonstrate that EWG genetically interacts with Wingless and Notch, and also with TGF-beta and AP-1 pathways in the regulation of synaptic growth.

CONCLUSION:

Our results show that EWG restricts synaptic growth by integrating multiple cellular signaling pathways into an extensive regulatory gene expression network.

PMID:
18419806
[PubMed - indexed for MEDLINE]
PMCID:
PMC2643944
Free PMC Article

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