Display Settings:

Format

Send to:

Choose Destination
Neuroreport. 2008 May 7;19(7):703-9. doi: 10.1097/WNR.0b013e3282fb8203.

Residual functional connectivity in the split-brain revealed with resting-state functional MRI.

Author information

  • 1New York University Child Study Center, New York, NY 10016, USA. lucina.uddin@med.nyu.edu

Abstract

Split-brain patients present a unique opportunity to address controversies regarding subcortical contributions to interhemispheric coordination. We characterized residual functional connectivity in a complete commissurotomy patient by examining patterns of low-frequency BOLD functional MRI signal. Using independent components analysis and region-of-interest-based functional connectivity analyses, we demonstrate bilateral resting state networks in a patient lacking all major cerebral commissures. Compared with a control group, the patient's interhemispheric correlation scores fell within the normal range for two out of three regions examined. Thus, we provide evidence for bilateral resting state networks in a patient with complete commissurotomy. Such continued interhemispheric interaction suggests that, at least in part, cortical networks in the brain can be coordinated by subcortical mechanisms.

PMID:
18418243
[PubMed - indexed for MEDLINE]
PMCID:
PMC3640406
Free PMC Article

Images from this publication.See all images (4)Free text

Fig. 1
Fig. 2
Fig. 3
Figure 4
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins Icon for PubMed Central
    Loading ...
    Write to the Help Desk