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J Virol. 2008 Jul;82(13):6772-7. Epub 2008 Apr 16.

Primate lentivirus capsid sensitivity to TRIM5 proteins.

Kratovac Z, Virgen CA, Bibollet-Ruche F, Hahn BH, Bieniasz PD, Hatziioannou T.

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Aaron Diamond AIDS Research Center and the Rockefeller University, New York, NY 10016, USA.

Abstract

Mammalian cells express several factors that inhibit lentiviral infection and that have been under strong selective pressure. One of these factors, TRIM5, targets the capsid protein of incoming retrovirus particles and inhibits subsequent steps of the replication cycle. By substituting human immunodeficiency virus type 1 capsid, we were able to show that a set of divergent primate lentivirus capsids was generally not susceptible to restriction by TRIM5 proteins from higher primates. TRIM5alpha proteins from other primates exhibited distinct restriction specificities for primate lentivirus capsids. Finally, we identified novel primate lentiviral capsids that are targeted by TRIMCyp proteins.

PMID:: 18417575; [PubMed - indexed for MEDLINE]
PMCID:: PMC2447065

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Cited by 10 PubMed Central articles

Role of TRIM5α RING domain E3 ubiquitin ligase activity in capsid disassembly, reverse transcription blockade, and restriction of simian immunodeficiency virus. [J Virol. 2011]
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