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Bioinformatics. 2008 Jun 1;24(11):1408-9. doi: 10.1093/bioinformatics/btn179. Epub 2008 Apr 15.

Forward-time simulations of non-random mating populations using simuPOP.

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  • 1Department of Epidemiology, The University of Texas, M. D. Anderson Cancer Center, 1155 Pressler Blvd, Houston, TX 77030, USA.


Computer simulations play an important role in studies of non-random mating populations. Because of implementation difficulties, only very limited types of non-random mating schemes are provided in the currently available simulation programs. Starting with version 0.8.5, simuPOP provides a few mating schemes that can be used to simulate arbitrary non-random mating models. This article describes the concepts and methods behind these mating schemes and demonstrates their uses in a few examples, including partial self-mating, positive assortative mating, non-random outbreeding, and simulation of overlapping generations in age-structured populations.


simuPOP is freely available at, distributed under a GPL license. Cited examples are in the doc/cookbook directory of a simuPOP distribution.

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