Retrovirus Center and Virology Section, Department of Experimental Pathology, University of Pisa, Via del Brennero 2, I-56127 Pisa, Italy. freer@biomed.unipi.it
Immunotherapy of feline immunodeficiency virus (FIV)-infected cats with monocyte-derived dendritic cells (MDCs) loaded with aldrithiol-2 (AT2)-inactivated homologous FIV was performed. Although FIV-specific lymphoproliferative responses were markedly increased, viral loads and CD4+ T cell depletion were unaffected, thus indicating that boosting antiviral cell-mediated immunity may not suffice to modify infection course appreciably.