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Cell Cycle. 2008 Apr 1;7(7):870-3. Epub 2008 Jan 14.

A spoke in the wheel: calcium spikes disrupt yeast cell cycle.

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  • 1Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.


A prerequisite of calcium signaling is the maintenance of cytoplasmic free Ca(2+) within a narrow, sub-micromolar range, compatible with cell viability. A variety of stress inducing agents and drugs can lead to a disruption of calcium homeostasis with ensuing toxicity. Amiodarone, an anti-arrhythmic drug with broad range microbicidal effect, has been shown to trigger a calcium burst in the yeast Saccharomyces cerevisiae. Recently, we reported that amiodarone elicits a starvation response, blocks cell cycle progression at multiple stages and represses the transcription of cell cycle genes. Here, we examine the connections between Ca(2+)-calcineurin signaling, nutrient sensing and regulation of the cell cycle.

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