Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Cancer Res. 2008 Apr 15;68(8):2557-60. doi: 10.1158/0008-5472.CAN-07-5989.

Role of the aggresome pathway in cancer: targeting histone deacetylase 6-dependent protein degradation.

Author information

  • 1Division of Hematology-Oncology, Mattel Children's Hospital, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095-1752, USA.

Erratum in

  • Cancer Res. 2009 May 1;69(9):4092.

Abstract

Misfolded or aggregated proteins have two fates: they are either refolded with the help of chaperones or degraded by the proteasome. Cells also have an alternative pathway that involves intracellular "storage bins" for misfolded intracellular proteins known as aggresomes. Aggresomes recruit motor proteins that transport misfolded or aggregated proteins to chaperones and proteasomes for subsequent destruction. There is emerging evidence that inhibiting the aggresome pathway leads to accumulation of misfolded proteins and apoptosis in tumor cells through autophagy. We discuss the role of aggresomes in cancer and the potential to target this pathway for therapy.

PMID:
18413721
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk