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    Cancer Res. 2008 Apr 15;68(8):2551-6.

    The quest for the 1p36 tumor suppressor.

    Bagchi A, Mills AA.

    Source

    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

    Abstract

    Genomic analyses of late-stage human cancers have uncovered deletions encompassing 1p36, thereby providing an extensive body of literature supporting the idea that a potent tumor suppressor resides in this interval. Although several genes have been proposed as 1p36 candidate tumor suppressors, convincing evidence that their encoded products protect from cancer has been scanty. A recent functional study identified chromodomain helicase DNA-binding protein 5 (CHD5) as a novel tumor suppressor mapping to 1p36. Here, we discuss evidence supporting the tumor-suppressive role of CHD5. Together, these findings suggest that strategies designed to enhance CHD5 activity could provide novel approaches for treating a broad range of human malignancies.

    PMID:
    18413720
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2980353
    Free PMC Article

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