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Genes Dev. 2008 Apr 15;22(8):970-5. doi: 10.1101/gad.1669408.

Small RNA guides for de novo DNA methylation in mammalian germ cells.

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  • 1Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.

Abstract

Germline genomic methylation is essential for gamete identity and integrity in mammals. The study by Kuramochi-Miyagawa and colleagues (908-917) in the previous issue of Genes & Development links the process of DNA methylation-dependent repression of retrotranspons with the presence of piwi-interacting RNAs (piRNAs) in fetal male germ cells undergoing de novo methylation.

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PMID:
18413711
[PubMed - indexed for MEDLINE]
PMCID:
PMC2732394
Free PMC Article

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