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    Philos Trans A Math Phys Eng Sci. 2008 Jul 13;366(1874):2301-12. doi: 10.1098/rsta.2008.0034.

    A Bayesian precision profile for measuring the quality of immunoassay experiments.

    Source

    Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston, MA 02115-5899, USA. omalley@hcp.med.harvard.edu

    Abstract

    A precision profile, the relationship between the concentration of a substance and its measured precision, is a convenient way of conveying the ability of an immunoassay to accurately measure the concentration of a substance in blood serum. A precision profile is characterized by the definition of precision. Historically, precision has been evaluated as the standard error of an estimator of the concentration in a sample conditional on the true concentration. In this paper, Bayesian predictive inference is used to develop a new measure of precision based on the accuracy with which an assay could infer the concentration in a hypothetical new sample. This leads to a natural procedure for evaluating a precision profile that avoids using approximations such as those inherent in traditional methods.

    PMID:
    18407899
    [PubMed - indexed for MEDLINE]

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