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Fertil Steril. 2008 Apr;89(4):759-79. doi: 10.1016/j.fertnstert.2008.02.096.

Asherman syndrome--one century later.

Author information

  • 1Hysteroscopic Center, Fu Xing Hospital, Capital Medical University, Beijing, People's Republic of China. yudanny2006@yahoo.com.cn

Abstract

OBJECTIVE:

To provide an update on the current knowledge of Asherman syndrome.

DESIGN:

Literature review.

SETTING:

The worldwide reports of this disease.

PATIENT(S):

Patients with Asherman syndrome who presented with amenorrhea or hypomenorrhea, infertility, or recurrent pregnancy loss.

INTERVENTION(S):

Hysteroscopy and hysteroscopic surgery have been the gold standard of diagnosis and treatment respectively for this condition.

MAIN OUTCOME MEASURE(S):

The etiology, pathology, symptomatology, diagnosis, treatment, and reproductive outcomes were analyzed.

RESULT(S):

This syndrome occurs mainly as a result of trauma to the gravid uterine cavity, which leads to the formation of intrauterine and/or intracervical adhesions. Despite the advances in hysteroscopic surgery, the treatment of moderate to severe Asherman syndrome still presents a challenge. Furthermore, pregnancy after treatment remains high risk with complications including spontaneous abortion, preterm delivery, intrauterine growth restriction, placenta accrete or praevia, or even uterine rupture.

CONCLUSION(S):

The management of moderate to severe disease still poses a challenge, and the prognosis of severe disease remains poor. Close antenatal surveillance and monitoring are necessary for women who conceive after treatment.

PMID:
18406834
[PubMed - indexed for MEDLINE]
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