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Curr Opin Biotechnol. 2008 Apr;19(2):190-7. doi: 10.1016/j.copbio.2008.02.015. Epub 2008 Apr 9.

Seeing is believing: engineering anthocyanin and carotenoid biosynthetic pathways.

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  • 1Institute for Plant Science, Suntory, Ltd., 1-1-1 Wakayamadai, Shimamoto, Mishima, Osaka 618-8503, Japan. Yoshikazu_Tanaka@suntory.co.jp


The biosynthetic pathways of flavonoids and carotenoids have been well established, and the biosynthetic genes have been mostly isolated. Metabolic engineering of their biosynthetic pathways has provided not only novel colored or health-beneficial plants but also excellent models to study the efficacy of such engineering. In order to achieve a specific color by accumulating a corresponding compound, it is necessary to upregulate the pathway leading to the compound and downregulate the competing pathway. The regulation of gene expression has to be optimized in a target crop as well.

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