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Neuro Oncol. 2008 Jun;10(3):236-43. doi: 10.1215/15228517-2008-006. Epub 2008 Apr 10.

GRP78 is overexpressed in glioblastomas and regulates glioma cell growth and apoptosis.

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  • 1Department of Neurosurgery and Hermelin Brain Tumor Center, Henry Ford Health System, Detroit, MI 48202, USA.

Abstract

We characterized the expression and function of the endoplasmic reticulum protein GRP78 in glial tumors. GRP78 is highly expressed in glioblastomas but not in oligodendrogliomas, and its expression is inversely correlated with median patient survival. Overexpression of GRP78 in glioma cells decreases caspase 7 activation and renders the cells resistant to etoposide- and cisplatin-induced apoptosis, whereas silencing of GRP78 decreases cell growth and sensitizes glioma cells to etoposide, cisplatin, and gamma-radiation. Thus, GRP78 contributes to the increased apoptosis resistance and growth of glioma cells and may provide a target for enhancing the therapeutic responsiveness of these tumors.

PMID:
18403493
[PubMed - indexed for MEDLINE]
PMCID:
PMC2563046
Free PMC Article
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