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Physiology (Bethesda). 2008 Apr;23:95-103. doi: 10.1152/physiol.00045.2007.

Apical transporters for neutral amino acids: physiology and pathophysiology.

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  • 1School of Biochemistry and Molecular Biology, Australian National University, Canberra, Australia.


Absorption of amino acids in kidney and intestine involves a variety of transporters for different groups of amino acids. This is illustrated by inherited disorders of amino acid absorption, such as Hartnup disorder, cystinuria, iminoglycinuria, dicarboxylic aminoaciduria, and lysinuric protein intolerance, affecting separate groups of amino acids. Recent advances in the molecular identification of apical neutral amino acid transporters has shed a light on the molecular basis of Hartnup disorder and iminoglycinuria.

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