Pediatr Infect Dis J. 2008 May;27(5):464-5. doi: 10.1097/INF.0b013e31816591f7.

Safety of a fifth dose of diphtheria and tetanus toxoid and acellular pertussis vaccine in children experiencing extensive, local reactions to the fourth dose.

Rennels MB, Black S, Woo EJ, Campbell S, Edwards KM.

Source

Department of Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD, USA.

Abstract

Extensive local reactions have been reported after booster doses of diphtheria and tetanus toxoid and acellular pertussis vaccine, but few data are available on revaccination after these reactions. Of 20 children with extensive local reactions after dose 4, only 4 experienced entire upper arm swelling and 7 had swelling >5 cm after dose 5. These reactions were well tolerated and support revaccination.

PMID:: 18398385; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

Research Support, U.S. Gov't, P.H.S.

MeSH Terms

Substances

Diphtheria-Tetanus-acellular Pertussis Vaccines

Grant Support

200-20002-00732/PHS HHS/United States

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Cited by 2 PubMed Central articles

Relative Contribution of Th1 and Th17 Cells in Adaptive Immunity to Bordetella pertussis: Towards the Rational Design of an Improved Acellular Pertussis Vaccine. [PLoS Pathog. 2013]
Relative Contribution of Th1 and Th17 Cells in Adaptive Immunity to Bordetella pertussis: Towards the Rational Design of an Improved Acellular Pertussis Vaccine.
Ross PJ, Sutton CE, Higgins S, Allen AC, Walsh K, Misiak A, Lavelle EC, McLoughlin RM, Mills KH. PLoS Pathog. 2013 Apr; 9(4):e1003264. Epub 2013 Apr 4.
Frequency of medically attended adverse events following tetanus and diphtheria toxoid vaccine in adolescents and young adults: a Vaccine Safety Datalink study. [BMC Infect Dis. 2009]
Frequency of medically attended adverse events following tetanus and diphtheria toxoid vaccine in adolescents and young adults: a Vaccine Safety Datalink study.
Jackson LA, Yu O, Belongia EA, Hambidge SJ, Nelson J, Baxter R, Naleway A, Gay C, Nordin J, Baggs J, et al. BMC Infect Dis. 2009 Oct 5; 9:165. Epub 2009 Oct 5.

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Safety of a fifth dose of diphtheria and tetanus toxoid and acellular pertussis vaccine in children experiencing extensive, local reactions to the fourth dose.
Pediatr Infect Dis J. 2008 May ;27(5):464-5. doi: 10.1097/INF.0b013e31816591f7.

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