Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Cell Stem Cell. 2008 Apr 10;2(4):380-91. doi: 10.1016/j.stem.2008.01.015.

The transcription factor EGR1 controls both the proliferation and localization of hematopoietic stem cells.

Author information

  • 1Section on Developmental and Stem Cell Biology, Joslin Diabetes Center, Boston, MA 02115, USA.

Abstract

EGR1 is a member of the immediate early response transcription factor family and functions in cell growth, development, and stress responses in many tissues. Here we report an additional role for EGR1 in regulating homeostasis of hematopoietic stem cells (HSCs). HSCs normally express Egr1 at high levels, but dramatically downregulate its expression when induced to divide and migrate. Consistent with this finding, mice lacking Egr1 exhibit significant increases in steady-state levels of dividing HSCs in the bone marrow (BM), and a striking spontaneous mobilization of HSCs into the peripheral blood. These data identify EGR1 as a transcriptional regulator of stem cell migration that normally functions to promote HSC quiescence and retention in the niche. The ability of this single factor to regulate both proliferation and mobilization of HSCs suggests that EGR1 commands a genetic program that coordinates stem cell division and migration to maintain appropriate HSC number and function.

Comment in

PMID:
18397757
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk