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Curr Biol. 2008 Apr 8;18(7):R302-4. doi: 10.1016/j.cub.2008.02.021.

Innate immunity: squelching anti-viral signalling with NLRX1.

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  • 1School of Biochemistry and Immunology, Trinity College Dublin, Ireland. laoneill@tcd.ie


Innate immunity to viruses involves receptors such as RIG-I, which senses viral RNA and triggers a signalling pathway involving the outer mitochondrial membrane protein MAVS. Recent work has identified that NLRX1, a member of another class of innate immune receptors, sequesters MAVS away from RIG-I and thereby prevents mitochondrial anti-viral immunity.

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