Your browser version may not work well with NCBI's Web applications. More information here...
1: J Anal Toxicol. 2008 Apr;32(3):232-40.Click here to read Links

Analysis of confiscated black market drugs using chromatographic and mass spectrometric approaches.

Thevis M, Schrader Y, Thomas A, Sigmund G, Geyer H, Schänzer W.

Center for Preventive Doping Research-Institute of Biochemistry, German Sport University Cologne, Carl-Diem Weg 6, 50933 Cologne, Germany. m.thevis@biochem.dshs-koeln.de

In the context of house searches in Germany, numerous drugs were confiscated and subjected to chemical analysis, including anabolic agents such as various anabolic-androgenic steroids (stanozolol, testosterone derivatives, trenbolone esters, etc.) and clenbuterol, as well as agents with anti-estrogenic activity (tamoxifen, clomiphene), drugs stimulating virility (sildenafil, tadalafil), and unlabeled plastic bags. Liquid chromatography-tandem mass spectrometry, gas chromatography-mass spectrometry with nitrogen-phosphorus specific detection, gel electrophoresis, and immunological tests were employed to test for the effective content of 70 products. In 18 cases (25.7%), the declared ingredients differed from the actual content, in particular concerning anabolic-androgenic steroids. Nandrolone and trenbolone esters, for instance, were frequently substituted or complemented by various testosterone derivatives, and several testosterone depot formulations originally composed of four different esters were found to contain fewer or wrong components. Except for those drugs supposedly originating from so-called underground labs, fake packings were hardly or not distinguishable from original boxes by visual inspection.

PMID: 18397575 [PubMed - indexed for MEDLINE]

Patient Drug Information

  • Tamoxifen (Nolvadex® )

    Your doctor has prescribed tamoxifen for you. Tamoxifen comes as a tablet to take by mouth.

  • Clomiphene (Clomid® , Serophene® )

    Clomiphene is used to induce ovulation (egg production) in women who do not produce ova (eggs) but wish to become pregnant (infertility). Clomiphene is in a class of medications called ovulatory stimulants. It works simi...

  • Sildenafil (Revatio® , Viagra® )

    Sildenafil (Viagra) is used to treat erectile dysfunction (impotence; inability to get or keep an erection) in men. Sildenafil (Revatio) is used to improve the ability to exercise in people with pulmonary arterial hypert...

  • » See all 4 drug reports ...
  • Source: AHFS Consumer Medication Information