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Insect Mol Biol. 2008 Jun;17(3):217-25. doi: 10.1111/j.1365-2583.2008.00797.x. Epub 2008 Apr 7.

Cloning and molecular characterization of two invertebrate-type lysozymes from Anopheles gambiae.

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  • 1Department of Entomology, University of Wisconsin, Madison, Wisconsin, USA.


We sequenced and characterized two novel invertebrate-type lysozymes from the mosquito Anopheles gambiae. Alignment and phylogenetic analysis of these and a number of related insect proteins identified through bioinformatics strategies showed a high degree of conservation of this protein family throughout the Class Insecta. Expression profiles were examined for the two mosquito genes through semiquantitative and real-time PCR analysis. Lys i-1 transcripts were found in adult females in the fat body and Malpighian tubules, whereas Lys i-2 was detected only in fat bodies. Blood-feeding resulted in significantly increased transcript abundance for both genes in the midguts. Neither gene was upregulated following bacterial challenge.

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