Cell Metab. 2008 Apr;7(4):288-90.

Iron homeostasis: fitting the puzzle pieces together.

Source

Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095-1690, USA. tganz@mednet.ucla.edu

Abstract

Here, recent insights into iron homeostasis are highlighted. Three studies demonstrate the importance of the IRE-IRP system for enterocytes in balancing extracellular iron demand against cellular iron requirements, show that the hemochromatosis protein HFE exerts its iron-regulatory activity principally in hepatocytes by modulating the production of hepcidin, and provide strong support for a proposed mechanism of transcriptional regulation of hepcidin through a signaling cascade initiated by holotransferrin displacing HFE from transferrin receptor 1.

PMID:: 18396134; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

IRON - HSDB

Supplemental Content

Related citations

Regulatory networks for the control of body iron homeostasis and their dysregulation in HFE mediated hemochromatosis. [J Cell Physiol. 2005]
Regulatory networks for the control of body iron homeostasis and their dysregulation in HFE mediated hemochromatosis.
Ludwiczek S, Theurl I, Bahram S, Schümann K, Weiss G. J Cell Physiol. 2005 Aug; 204(2):489-99.
Iron sensing as a partnership: HFE and transferrin receptor 2. [Cell Metab. 2009]
Iron sensing as a partnership: HFE and transferrin receptor 2.
Fleming RE. Cell Metab. 2009 Mar; 9(3):211-2.
Function of the hemochromatosis protein HFE: Lessons from animal models. [World J Gastroenterol. 2008]
Function of the hemochromatosis protein HFE: Lessons from animal models.
Pantopoulos K. World J Gastroenterol. 2008 Dec 7; 14(45):6893-901.
Review New insights into iron homeostasis through the study of non-HFE hereditary haemochromatosis. [Best Pract Res Clin Haematol. 2005]
Review New insights into iron homeostasis through the study of non-HFE hereditary haemochromatosis.
Roetto A, Camaschella C. Best Pract Res Clin Haematol. 2005 Jun; 18(2):235-50.
Review Hepcidin: a putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease. [Proc Natl Acad Sci U S A. 2001]
Review Hepcidin: a putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease.
Fleming RE, Sly WS. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8160-2.

See reviews... See all...

Cited by 12 PubMed Central articles

Diagnosis and management of hemochromatosis: 2011 practice guideline by the American Association for the Study of Liver Diseases. [Hepatology. 2011]
Diagnosis and management of hemochromatosis: 2011 practice guideline by the American Association for the Study of Liver Diseases.
Bacon BR, Adams PC, Kowdley KV, Powell LW, Tavill AS, American Association for the Study of Liver Diseases. Hepatology. 2011 Jul; 54(1):328-43.
Review Human iron-sulfur cluster assembly, cellular iron homeostasis, and disease. [Biochemistry. 2010]
Review Human iron-sulfur cluster assembly, cellular iron homeostasis, and disease.
Ye H, Rouault TA. Biochemistry. 2010 Jun 22; 49(24):4945-56.
The role of hepatocyte hemojuvelin in the regulation of bone morphogenic protein-6 and hepcidin expression in vivo. [J Biol Chem. 2010]
The role of hepatocyte hemojuvelin in the regulation of bone morphogenic protein-6 and hepcidin expression in vivo.
Zhang AS, Gao J, Koeberl DD, Enns CA. J Biol Chem. 2010 May 28; 285(22):16416-23. Epub 2010 Apr 2.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Iron homeostasis: fitting the puzzle pieces together.
Iron homeostasis: fitting the puzzle pieces together.
Cell Metab. 2008 Apr ;7(4):288-90.

PubMed
The impact of the transcendental meditation program on government payments to ph...
The impact of the transcendental meditation program on government payments to physicians in Quebec: an update.
Am J Health Promot. 2000 May-Jun ;14(5):284-91.

PubMed
Epidemiology of trauma deaths.
Epidemiology of trauma deaths.
Am J Surg. 1980 Jul ;140(1):144-50.

PubMed
Comparative genomics of the fungal pathogens Candida dubliniensis and Candida al...
Comparative genomics of the fungal pathogens Candida dubliniensis and Candida albicans.
Genome Res. 2009 Dec ;19(12):2231-44. Epub 2009 Sep 10 .

PubMed
Captopril suppression versus salt loading in confirming primary aldosteronism.
Captopril suppression versus salt loading in confirming primary aldosteronism.
Hypertension. 2001 Jun ;37(6):1440-3.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Iron homeostasis: fitting the puzzle pieces together.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

Supplemental Content

Related citations

Cited by 12 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information