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Eur J Immunol. 2008 Apr;38(4):931-4. doi: 10.1002/eji.200738108.

Clinical application of regulatory T cells for treatment of type 1 diabetes and transplantation.

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  • 1UCSF Diabetes Center, University of California, San Francisco, San Francisco, CA 941430540, USA.


Immune regulation is a complex process that depends on the maintenance of self tolerance while retaining robust immune responses against microbes. The emergence of Treg as a central mechanism for immune regulation has generated a new paradigm where Treg-resistant memory T cells and/or "defective" Treg lead to a breakdown in tolerance resulting in immune pathology. In this perspective, we highlight the opportunities and challenges in the field of Treg therapy.

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