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    Neurotoxicology. 2008 May;29(3):532-45. Epub 2008 Feb 23.

    Immunologic and neurodevelopmental susceptibilities of autism.

    Source

    School of Veterinary Medicine, University of California, Davis, CA 95616, USA. inpessah@ucdavis.edu

    Abstract

    Symposium 5 focused on research approaches that are aimed at understanding common patterns of immunological and neurological dysfunction contributing to neurodevelopmental disorders such as autism and ADHD. The session focused on genetic, epigenetic, and environmental factors that might act in concert to influence autism risk, severity and co-morbidities, and immunological and neurobiological targets as etiologic contributors. The immune system of children at risk of autism may be therefore especially susceptible to psychological stressors, exposure to chemical triggers, and infectious agents. Identifying early biomarkers of risk provides tangible approaches toward designing studies in animals and humans that yield a better understanding of environmental risk factors, and can help identify rational intervention strategies to mitigate these risks.

    PMID:
    18394707
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2475601
    Free PMC Article

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