Cancer Cell. 2008 Apr;13(4):289-91.

C/EBPalpha in leukemogenesis: a matter of being in the right place with the right signals.

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Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA. lucio.castilla@umassmed.edu

Abstract

Leukemia-initiating cells can originate from hematopoietic progenitor cells that have acquired self-renewal capacity upon transformation with leukemic fusion genes. In this issue of Cancer Cell, Kirstetter and colleagues describe a mouse model for the frequent CEBPA mutations in human acute myeloid leukemia that result in the synthesis of only the 30kDa isoform, but not the 42kDa isoform of C/EBPalpha. This mutation uncouples C/EBPalpha's roles in myeloid differentiation and proliferation control. Furthermore, this mutation activates self-renewal in committed myeloid progenitor cells and induces myeloid malignancy with complete penetrance that is sustained by leukemia-initiating cells with a committed myeloid molecular signature.

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Cancer Cell. 2008 Apr;13(4):299-310.

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