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Expert Rev Vaccines. 2008 Apr;7(3):319-31. doi: 10.1586/14760584.7.3.319.

Tenets of protection from progression to AIDS: lessons from the immune responses to HIV-2 infection.

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  • 1Medical Research Council Laboratories, Fajara, Atlantic Road, PO Box 273, The Gambia, West Africa. srowland-jones@mrc.gm


In the past 25 years, life survival curves of many countries have been remodeled owing to HIV infection. Both HIV-1 and HIV-2 can cause AIDS, yet patients infected with HIV-2 fare much better clinically and most will never experience detrimental effects of the infection. Despite over two decades of comprehensive research into vaccine development, a prophylactic vaccine is not yet realized. An essential missing link in the innovation of a successful vaccine strategy is the description of a favorable immune response that abolishes virus replication. Lessons learned from studying the role of the immune system in the long-term nonprogression characteristic of HIV-2 infection will offer insight into how a balanced immune response can protect from the destruction of the immune system associated with chronic HIV-1 infection.

[PubMed - indexed for MEDLINE]
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