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[Association of the XRCC1 and hOGG1 polymorphisms with the risk of laryngeal carcinoma].

[Article in Chinese]

Author information

  • 1Department of Laboratory Medicine, Huaihua Medical College, Huaihua, Hunan, 418000 P. R. China. yang1977yuan@yahoo.com.cn

Abstract

OBJECTIVE:

To evaluate the association between the polymorphisms of X-ray repair cross complementing group 1 (XRCC1) and human 8-oxoguanine glycosylase I (hOGG1) gene and the risk for laryngeal carcinoma.

METHODS:

This is a case-control study comprised of two groups: 72 patients with laryngeal squamous carcinoma, and 72 controls without laryngeal carcinoma. The PCR-restriction fragment length polymorphism method was used to analyze the XRCC1-Arg399Gln, hOGG1-Ser326Cys polymorphisms.

RESULTS:

The frequencies of XRCC1-399Arg/Gln+ Gln/Gln and hOGG1-326Ser/Cys+ Cys/Cys genotypes in the case group were higher than that of the control group(P< 0.05). There was a 3.37-fold or 2.54-fold increased risk of laryngeal carcinoma for individuals carrying XRCC1-399Arg/Gln+ Gln/Gln or hOGG1-326Ser/Cys+ Cys/Cys genotypes, compared with subjects carrying XRCC1-Arg/Arg or hOGG1-Ser/Ser genotype, respectively. No statistically significant differences were found between the smoking group and non-smoking group for risk of laryngeal carcinoma.

CONCLUSION:

The amino acid replacement of XRCC1-399Arg to Gln and hOGG1-326Ser to Cys might lead to an increased risk of laryngeal carcinoma. The study demonstrated the positive association between the polymorphisms of XRCC1 and hOGG1 genes and laryngeal carcinoma.

PMID:
18393249
[PubMed - indexed for MEDLINE]
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