Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Intensive Care Med. 2008 Jun;34(6):1012-9. doi: 10.1007/s00134-008-1087-7. Epub 2008 Apr 8.

Triggering receptors expressed on myeloid cells in pulmonary aspiration syndromes.

Author information

  • 1Western New York Respiratory Research Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, State University of New York at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY, USA. solh@buffalo.edu

Abstract

OBJECTIVE:

To investigate the potential role of serum and alveolar soluble triggering receptor expressed on myeloid cells (sTREM-1) as a biological marker of pulmonary aspiration syndromes.

DESIGN:

Prospective cohort study.

SETTING:

University-affiliated intensive care unit.

PATIENTS:

Seventy-five patients with pulmonary aspiration and 13 controls receiving mechanical ventilation.

INTERVENTIONS:

Blood and bronchoalveolar lavage (BAL) fluid samples were collected on enrollment. Soluble TREM-1 levels were measured by an enzyme-linked immunosorbent assay.

MEASUREMENTS AND RESULTS:

Thirty-eight of 75 participants had documented BAL culture-positive pulmonary aspiration. While circulating levels of sTREM-1 were comparable between those with aspiration syndromes (19.81 +/- 12.09 pg/ml) and controls (15.96 +/- 11.16 pg/ml) (p=0.27), the alveolar levels of sTREM-1 were higher in patients with culture-positive pulmonary aspiration (344.41 +/- 152.82 pg/ml) compared with those culture-negative pulmonary aspiration (142.76 +/- 89.88 pg/ml; p < 0.001). A cut-off value of 250 pg/ml for alveolar sTREM-1 achieved a sensitivity of 65.8% (95% CI 48.6-80.4) and a specificity of 91.9% (95% CI 78.1-98.2) with an area under the curve of 0.87 (95% CI 0.78-0.94).

CONCLUSIONS:

Alveolar sTREM-1 levels can be a potential biomarker for distinguishing BAL culture-positive from BAL culture-negative pulmonary aspiration.

Comment in

PMID:
18392807
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Springer
    Loading ...
    Write to the Help Desk