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J Clin Rheumatol. 2008 Apr;14(2):92-3. doi: 10.1097/RHU.0b013e31816b4487.

Effect of rituximab on refractory Wegener granulomatosis with predominant granulomatous disease.

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  • 1Unidad de Enfermedades Autoinmunes Sistémicas, Hospital Universitario San Cecilio, Granada, Spain. danifilax@gmail.com


Wegener granulomatosis is an autoimmune disorder with a double spectrum. Vasculitic manifestations are at one end of it, whereas granulomatous ones are at the other. Rituximab (RTX) is a chimeric monoclonal antibody that has been successfully used in this condition. However, the granulomatous forms have been reported to show a tendency to be less responsive to RTX than the vasculitic disease. We present 4 cases of predominantly Wegener granulomatosis that responded positively to RTX.

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