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Antimicrob Agents Chemother. 2008 Jun;52(6):2256-9. doi: 10.1128/AAC.00070-08. Epub 2008 Apr 7.

Increasing incidence of linezolid-intermediate or -resistant, vancomycin-resistant Enterococcus faecium strains parallels increasing linezolid consumption.

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  • 1Midwestern University Chicago College of Pharmacy, Infectious Diseases Pharmacist, Northwestern Memorial Hospital, 251 E. Huron St., Feinberg Pavilion LC-700, Chicago, IL 60611, USA. mscheetz@nmh.org

Abstract

Clinical enterococcal resistance to linezolid is defined by the presence of the G2576T mutation. We evaluated the incidence of genetically proven linezolid resistance among vancomycin-resistant Enterococcus faecium strains and linezolid consumption for a possible association. A relationship was found (r(2) = 0.73, P = 0.03) and predicts increasing resistance with current trends of linezolid use.

PMID:
18391028
[PubMed - indexed for MEDLINE]
PMCID:
PMC2415807
Free PMC Article
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