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Clin Pharmacol Ther. 2008 Jun;83(6):909-12. doi: 10.1038/clpt.2008.52. Epub 2008 Mar 26.

Development of translational pharmacokinetic-pharmacodynamic models.

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  • 1Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York, USA.


Contemporary models in the field of pharmacokinetic-pharmacodynamic (PK-PD) modeling often incorporate the fundamental principles of capacity limitation and operation of turnover processes to describe the time course of pharmacological effects in mechanistic terms. This permits the identification of drug- and system-specific factors that govern drug responses. There is considerable interest in utilizing mechanism-based PK-PD models in translational pharmacology, whereby in silico, in vitro, and preclinical data may be effectively coupled with relevant models to streamline the discovery and development of new therapeutic agents. These translational PK-PD models form the subject of this review.

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