Neurol Res. 2008 Feb;30(1):5-16.

Stem and progenitor cell therapies: recent progress for spinal cord injury repair.

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The Miami Project to Cure Paralysis, University of Miami School of Medicine, Miami, FL 33136, USA.

Abstract

Mechanical trauma to the spinal cord is often accompanied by irreversible tissue damage, limited endogenous repair and permanent loss of motor, sensory and autonomic function. The implantation of exogenous cells or the stimulation of endogenous cells, to repopulate and replace or to provide a conducive environment for repair, offers a promising therapeutic direction for overcoming the multitude of obstacles facing successful recovery from spinal cord injury. Although relatively new to the scene of cell based therapies for reparative medicine, stem cells and their progenitors have been labeled as the 'cell of the future' for revolutionizing the treatment of CNS injury and neurodegenerative disorders. The following review examines the different types of stem cells and their progenitors, their utility in experimental models of spinal cord injury and explores the outstanding issues that still need to be addressed before they move towards clinical implementation.

PMID:: 18387258; [PubMed - indexed for MEDLINE]

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Lim JH, Piedrahita JA, Jackson L, Ghashghaei T, Olby NJ. Cell Reprogram. 2010 Dec; 12(6):689-97.
Transplantation of ciliary neurotrophic factor-expressing adult oligodendrocyte precursor cells promotes remyelination and functional recovery after spinal cord injury. [J Neurosci. 2010]
Transplantation of ciliary neurotrophic factor-expressing adult oligodendrocyte precursor cells promotes remyelination and functional recovery after spinal cord injury.
Cao Q, He Q, Wang Y, Cheng X, Howard RM, Zhang Y, DeVries WH, Shields CB, Magnuson DS, Xu XM, et al. J Neurosci. 2010 Feb 24; 30(8):2989-3001.
Suspension matrices for improved Schwann-cell survival after implantation into the injured rat spinal cord. [J Neurotrauma. 2010]
Suspension matrices for improved Schwann-cell survival after implantation into the injured rat spinal cord.
Patel V, Joseph G, Patel A, Patel S, Bustin D, Mawson D, Tuesta LM, Puentes R, Ghosh M, Pearse DD. J Neurotrauma. 2010 May; 27(5):789-801.

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