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J Neural Transm. 2008 Jun;115(6):937-40. doi: 10.1007/s00702-008-0041-8. Epub 2008 Apr 2.

Serum levels of S100B are decreased in chronic starvation and normalize with weight gain.

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  • 1Department of Child and Adolescent Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany. kholtkamp@ukaachen.de

Abstract

S100B protein is mainly synthesized in glial cells and modulates the balance between cell proliferation and differentiation in neurons and glial cells. However, S100B is not CNS-specific since its production was detected in numerous non-cerebral tissues e.g. adipocytes. In this study we investigated the influence of chronic fasting and subsequent weight gain on serum levels of S100B in patients with anorexia nervosa. We found that nutritional status was an important factor influencing serum levels of S100B.

PMID:
18385926
[PubMed - indexed for MEDLINE]
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