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Hum Vaccin. 2008 May-Jun;4(3):234-7. Epub 2010 May 6.

Changes in DT vaccine frequency and indications for use following introduction of DTaP vaccine.

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  • 1Group Health Center for Health Studies, Seattle, Washington 98101-1448, USA.


Our population-based study among HMO members under seven years of age in 1993-2000 showed that frequency of diphtheria and tetanus toxoid vaccine (DT) use declined significantly following the introduction of acellular pertussis-containing (DTaP) vaccine. We also observed changes in indications for DT following the transition to DTaP among children under two years of age; notably, a decline in the proportion of children receiving DT due to a reported prior vaccine reaction and an increase in the proportion of children receiving DT due to parental request and a history of pertussis.

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