Alpha-aminophosphonates as novel organocatalysts for asymmetric Michael addition of carbonyl compounds to nitroolefins

Chirality. 2008 Jul;20(7):833-8. doi: 10.1002/chir.20552.

Abstract

A cyclic alpha-aminophosphonate was found to be a novel organocatalyst for Michael type addition reactions of carbonyl compounds to nitroolefins to afford the corresponding adducts in high enantio- and diastereoselectivities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemical synthesis*
  • Alkenes / chemistry
  • Catalysis
  • Chemistry, Organic / methods
  • Chromatography, High Pressure Liquid
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Organophosphonates / chemistry*
  • Solvents
  • Stereoisomerism

Substances

  • Alkenes
  • Organophosphonates
  • Solvents