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Immunol Lett. 2008 May 15;117(2):123-30. doi: 10.1016/j.imlet.2008.01.011. Epub 2008 Mar 3.

Advances in understanding the anti-inflammatory properties of IL-27.

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  • 1University of Pennsylvania, School of Veterinary Medicine, Room 313, Hill Pavilion, 380 South University Avenue, Philadelphia, PA 19104-4539, United States.


Initial studies on the biology of IL-27 provided evidence of a role for this cytokine in the initiation of Th1 responses; however, subsequent work using models of pathogen-induced and autoimmune inflammation have indicated that IL-27 has broad inhibitory effects on Th1, Th2 and Th17 subsets of T cells as well as the expansion of inducible regulatory T cells. While, the aim of this review is to highlight the functions of IL-27 in the context of inflammation it will also serve to elaborate on the molecular mechanisms involved in the production of this cytokine. The initial description of IL-27 indicated that classical antigen-presenting cells such as macrophages and dendritic cells produce IL-27, however, the agonists and signaling pathways involved in activating transcription of the two subunits of IL-27, p28 and EBV-induced gene 3 (EBI3) have only recently been described.

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