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Environ Health Perspect. 1991 Jun;93:97-103.

Mechanisms of oncogene cooperation: activation and inactivation of a growth antagonist.

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  • 1Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139.

Abstract

Gene transfer experiments have defined limitations with regard to the ability of individual oncogenes to transform cultured cells to a tumorigenic state. The stable transformation of REF52 cells by either the ras or sis oncogenes requires the continuous expression of a second collaborating oncogene, such as adenovirus-5 E1A or SV40 large T-antigen. Our studies suggest that the function of the nuclear collaborators is to antagonize dominant growth controls which limit the ability of REF52 cells to proliferate in response to mitogenic stimuli.

PMID:
1837777
[PubMed - indexed for MEDLINE]
PMCID:
PMC1568054
Free PMC Article
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