Source
Department of Dermatology, University Hospital, Alcala de Henares University, Guadalajara, Spain. ediez@sescam.jccm.es
Abstract
BACKGROUND:
Unilesional mycosis fungoides (MF) is a rare variant of cutaneous T-cell lymphoma (CTCL), characterized clinically by a solitary lesion and by histopathological features indistinguishable from multilesional MF. The photodynamic therapy (PDT) is a new and effective treatment of precancerous lesions and non-melanoma skin cancers. In recent years it has been used successfully for the treatment of MF.
METHODS:
We present two cases of unilesional MF treated with 5-Aminolevulinic acid-PDT (ALA-PDT). We used twenty per cent ALA, applied topically to the lesion, and a well defined laser irradiation at 585 nm wavelength from C-Beam laser. Treatment was repeated three times at monthly intervals. Skin biopsies were taken before and after therapy.
RESULTS:
Both patients showed clinical remission. The biopsies confirmed a regression of the infiltrate after treatment.
CONCLUSIONS:
PDT is effective and can be used successfully for MF treatment, particularly for patch and plaque stage MF, including unilesional MF.